Definition of on one
on one 
verb
- to act out of the ordinary, as if one were on medication.
My mom was on one yesterday so I couldn't make any phone calls.
by D L., Los Angeles, CA, USA, Nov 14 1997.
Discover slang words with the same meaning:
Slang terms with the same root words:
- one: afraid of one's shadow – back to square one – (show 85 more)
- on: accidentally on purpose – a slap on the wrist – (show 277 more)
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